Aromatase Inhibitors

 Aromatase inhibitors are a class of drugs that block the formation of estrogen. They are currently FDA approved for the treatment of certain forms of breast cancer. However, recent studies indicate a possible role for these drugs in some women with reproductive problems. They have been used to induce ovulation in women who are not ovulating. They have also been used for the treatment of pelvic pain in women with endometriosis. The two drugs that have been studied in this context are letrozole (Femara) and anastrazole (arimidex). The role of aromatase inhibitors in the treatment of women with reproductive endocrine disorders remains to be established. Currently it is unclear whether or not they are better than our existing therapy. We currently offer therapy with these drugs to women who have not responded to standard treatment.